Physicochemical studies, residue studies, pharmacokinetic studies, biodegradation studies, efficacy studies of biocides.

- Statement of GLP compliance No 5/2009/GLP

Evaluation of biological effectivity
No. Study procedures Normative documents

 1

Insecticide activity expressed asLD50 

Own method

 2

Insecticide activity expressed as LC50

Own method

 3

Insecticide residual activity of aerosols and other ready-to-use form expressed as LT50

Own method

 4

Insecticide activity of pest bait

Own method.

 5

Insecticide efficacy of sticky traps

Own method

 6

Determination of insecticide efficacy of aerosols (in the room)

Own method

 7

Determination of larvicidal activity

Own method

 8

Examination of insecticidal efficacy of fumigation products

Own method

 


Determination of physical, chemical and technical properties of substances and chemical products

No. Study procedures Normative documents / own method

 1

Relative density of liquids and solids

OECD 109, ISO 649/1 and ISO 649/2, ISO 758:1976, ISO 3507:1999, ISO 901:1976, ISO 787-10:1993, PN-92/C-0504; CIPAC MT 3 and EEC A.3

 2

Determination of pH values

PN-C-04665:2001

and CIPAC MT 75

 3

Free acidity or alkalinity

PN-C-04665:2001

and CIPAC MT 31

 4

Kinematic and dynamic viscosity of Newtonian liquids

OECD 114 and PN-EN ISO 3104: 2002

and  PN-EN ISO 3105: 2002; PN-81/C-04011

 5

Viscosity of Newtonian and non - Newtonian fluids

PN-ISO 2555, PN-EN-ISO 3219:2000

and PN-EN 12092: 2004 ASTM D-2196-99

 6

Determination of Weight Loss of Tested Material

CIPAC MT 17

 7

Ambient temperature storage procedure

Technical Monograph GIFAP No 17

 8

Accelerated storage procedure

CIPAC MT 46

 9

Low temperature (0°C) storage procedure

CIPAC MT 39

 10

Low temperature (0°C) stability testing of liquids

CIPAC MT 39

 11

Dilution stability

CIPAC MT 41 and CIPAC MT 179

 12

Pourability of suspension concentrates

CIPAC MT 148

 13

Wettability

PN-87 C-04662 and CIPAC MT 53.3

 14

Suspensibility

PN-C-04654:1997

and CIPAC MT 15.1,

MT 161 and MT 168

 15

Emulsifiability, re-emulsifiability and emulsion stability, dispersion stability

Own method based on PN-C-04652:1998

and CIPAC MT 36

 16

Persistent foaming

PN-85/C-04661 and CIPAC MT 47

 17

Tap density

CIPAC MT 33, 159 and 169. 

 18

Dry sieve test

PN-71/C-04501 and CIPAC MT 59.1

and CIPAC MT 58.2

 19

Wet sieve test

PN-71/C-04501 and CIPAC MT 59.3

and CIPAC MT 167; CIPAC MT 185

 20

Dissolution rate of water soluble bags

CIPAC MT 176

 21

Packaging stability

Technical Monograph GIFAP No 17

 22

Pourability and effectiveness of cleaning procedures

Own method

 23

Appearance

Technical Monograph GIFAP No 17 .

 24

Determination of particle size distribution by Laser difraction

CIPAC MT 187

ISO 13320-1;1999

 25

Determination of the Spontaneity Dispersion of Suspension Concentrates

CIPAC MT 160
CIPAC MT 174

 26

Determination of Granular Product Dust Content

CIPAC MT 171

 27

Determination of pesticides solubility rate

CIPAC MT 60

 28

Determination of seed to seed uniformity of distribution for liquid seed-treatment formulations

CIPAC MT 175.

 29

Flowability of granules

CIPAC MT 172

 30

Measurement of the surface tension of aqueous solutions

OECD 115

EEC A.5

 31

Evaluation of solubility of chemical substances
in water, shake flask method

OECD 105
EEC A6

 32

Evaluation of solubility of chemical substances in organic solvents, shake flask method

OECD 105

EEC A.6

 33

Evaluation of  partition coefficient n-octanol/water, shake flask method

OECD 107

EEC A.8

 34

Determination of the melting temperature
of substances using capillary tube in liquid bath

OECD 102

EEC A1

 35

Determination of the boiling temperature of substances using capillary tube in liquid bath, the Siwoloboff method

OECD 103

EEC A2

 36

Evaluation of rate constants of hydrolysis in water of chemical substances

OECD 111
EEC C.7

 37

Evaluation of dissociation constants in water of chemical substances

OECD 112

 38

Determination of dissociation constants of chemical substances in water ,
spectrophotometric method

OECD 112

 39

Determination of dissociation constants of chemical substances in water, conductometric method

OECD 112

 40

Determination of crystallization temperature

PN ISO 1392
OECD 102

 41

Determination of the melting temperature of substances using capillary tube in metal block

OECD 102
EEC A.1

 42

Determination of the boiling temperature of substances using capillary tube in metal block

OECD 103

EEC A.2

 43

Determination of chemical substances water solubility: column elution method

OECD 105

EEC A.6.

 44

Determination of partition coefficient
(n-octanol/water), slow stirring method

OECD 123

 45

Determination of partition coefficient
(n-octanol/water), pH-metric method for ionisable substances

OECD 122

 46

Phototransformation of chemicals in water - direct and indirect photolysis

OECD 316

 47

Photodegradation of chemical substances on soil

OPPTS 835.2410

 48

Determination of dry matter and water content in soil on a dry soil mass basis

PN-ISO 11465  

 49

Thermal stability of chemical substances in air

OECD 113

 50

Refraction index determination

Farmakopea Poland wyd. VI 2002

 51

Determination of optical  rotation of chemical substances

Farmakopea Poland wyd. VI 2002

 52

Accelerated ageing test of chemical substances and the mixtures of them at 400C and 75% relative  humidity

According to no 75/318/EEC directive,

app. ICH Q1A

 53

Long term Accelerated ageing test of chemical substances and the mixtures of them at 250C and 60 % relative  humidity

According to no 75/318/EEC directive,

app. ICH Q1A

 54

Determination of vapor pressures of substances using gas saturation method

OECD 104

 EEC A.4

 55

Determination of vapor pressures of substances using static method

OECD 104

 EEC A.4

 56

Determination of vapour pressures of substances using effusion method with Knudsen cell.

OECD 104

 EEC A.4

 57

Determination of oxidizing properties of solids

EEC A.4

 58

Determination of oxidizing properties of solids

EEC A.17

 59

Determination of pyrophoric properties of solids and liquids

EEC A.13

 60

Determination of oxidizing properties of liquids

EEC A.21

 61

Determination of auto-ignition temperature (liquids)

EEC A.15

 62

Determining the minimum ignition temperatures of dust

PN-EN 50281-2-1:2002-12

 63

Flammability solids

EEC A.10

 64

Flash point

EEC A.9

 65

Determining the ability of solids to self-heating up to self-ignition

EEC A.10

 66

Determination of initial boiling point

Test UN N.4

 67

Determination of relative self-ignition temperature for solids

PN-ISO 918
ASTM D86-07
PN-EN ISO 3405: 2004

 68

Explosive properties

    Determination of impact sensitivityDetermination of friction sensitivityDetermination of thermal sensitivity

EEC A.14


 

Environmental studies

No.

Study procedures

Normative documents

 1

Ready aerobic biodegradability screening test of substances using manometric respirometry

OECD 301F

 EEC C.4-D

 2

Ready aerobic biodegradability screening test of substances using Dissolved Organic Carbon (DOC) die-away test

OECD 301 A
EEC C.4.A 

 3

Ready aerobic biodegradability screening test of substances using closed bottle method

OECD 301D    
EEC C.4.E

 4

Manometric respirometry measurement of biodegradation of substances in soil under aerobic conditions

PN-ISO 11266

DIN 19737

 5

Inherent aerobic biodegradability test of substances using Zahn-Wellens test

OECD 302 B
EEC C.9 

 6

Acivated sludge simulation test

OECD 303A
EEC C.10 

 7

Evaluation of the ultimate aerobic biodegradability and disintegration of packaging materials under controlled composting conditions - Method by analysis of released carbon dioxide

 

PN-EN 14046 

 8

Activated sludge respiration inhibition test

OECD  209 
EEC C.11

Ready biodegradability – CO2 in sealed vessels (Headspace Test)

OECD 310  

 10

Anaerobic biodegradability of organic compounds in digested sludge, by measurement of gas production

OECD 311

 11

Determination of the ultimate aerobic biodegradability of plastic materials in an aqueous medium  - Method by measuring the oxygen demand in a closed respirometer

EN ISO 14851